Allosteric Mechanisms Underlying Long QT Syndrome Type 2 (LQT2) Associated Mutations in hERG Channels
Audrey Deyawe Kongmeneck, Geraldine San Ramon, Brian P. Delisle, Peter Michael Kekenes-Huskey
This study uses molecular dynamics simulations to show that LQT2 mutations disrupt the selectivity filter structure, impairing channel trafficking, and that some variants can correct these defects.
bioRxiv · Apr 7, 2026 · PreprintBiophysics