Brian P. Delisle

The circadian clock regulates KCNH2 (hERG) promoter activity through daily temperature rhythms.

This study shows that temperature cycles drive circadian regulation of the KCNH2 promoter through BMAL1:CLOCK binding at a conserved E-box.

Light-cycle time-restricted feeding remodels a hidden layer of the cardiac transcriptome through sex-specific transcript switching

This study shows light-cycle time-restricted feeding alters cardiac transcript usage in a sex-specific manner, revealing previously undetected transcript-level regulation.

Housing Mice in Thermoneutrality Causes Tissue-specific Changes in Number, Identity, and Phase of Circadian-expressed mRNA Transcripts

This study shows that housing mice in thermoneutrality alters tissue-specific circadian gene expression without changing core clock genes.

Allosteric Mechanisms Underlying Long QT Syndrome Type 2 (LQT2) Associated Mutations in hERG Channels

This study uses molecular dynamics simulations to show that LQT2 mutations disrupt the selectivity filter structure, impairing channel trafficking, and that some variants can correct these defects.

New role of cardiomyocyte Bmal1 in the regulation of sex-specific heart transcriptomes

This study shows that cardiomyocyte Bmal1 is essential for sex-specific gene expression in the adult mouse heart, as its loss reduces sex differences in circadian transcriptomes.

Prediction of Kv11.1 potassium channel PAS-domain variants trafficking via machine learning

This study uses machine learning and molecular dynamics simulations to predict which KCNH2 variants disrupt Kv11.1 channel trafficking, improving variant classification accuracy by ~10%.

Defining the age-dependent and tissue-specific circadian transcriptome in male mice

This study identifies age-dependent and tissue-specific changes in the circadian transcriptome of male mice, showing reduced rhythmic gene expression and increased variability in aged tissues.