Melisa Benard-Valle

Odin-Multi is a binder design framework that optimizes sequences against multiple targets simultaneously, improving cross-reactivity and specificity compared to single-target methods.

This study designs de novo single-domain antibodies against cobra neurotoxin and shows they protect mice from lethal venom toxicity.

This paper develops a pipeline combining yeast screening and AlphaFold3 to accelerate discovery of multi-target antibodies, finding that structural predictions improve binding specificity and solubility.

Conditioning RFdiffusion on edge beta-strand pairing yields specific binders to polar targets, with in silico success above 9.2% versus 0.98% for hotspot-only conditioning.