Author

George C. Linderman

Yale UniversityORCID 0000-0002-0074-0346Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:dimensionality reduction· 1 Approach:experimental assay· 1 Assay:imaging· 1 Research Focus:imputation· 1 Approach:matrix factorization· 1 Organism:mouse· 1

Frequent Co-Authors

Dmitry KobakiD· 1 shared Jun ZhaoiD· 1 shared Yuval KlugeriD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

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3 top collaborators · 1 mutual co-author link

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1 shared paperBioinformatics

Dmitry KobakORCID

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2 papers

Recent·Most cited

UMAP does not preserve global structure any better than t-SNE when using the same initialization

Dmitry Kobak, George C. Linderman

The paper shows that UMAP's apparent superiority over t-SNE in preserving global structure is due to different initialization methods, not the algorithm itself.

Nature Biotechnology · Feb 1, 2021Peer-reviewedBioinformatics

Zero-preserving imputation of scRNA-seq data using low-rank approximation

George C. Linderman, Jun Zhao, Yuval Kluger

Truncated SVD plus a per-gene threshold at the most negative value fills dropouts while leaving biological zeros alone, and runs on 50,000 cells in about 40 minutes.

bioRxiv · Aug 22, 2018 · PreprintBioinformatics✦ In-depth digest