Robust coordination of collective oscillatory signaling requires single-cell excitability and fold-change detection
Chuqiao Huyan, Alexander Golden, Xinwen Zhu, Pankaj Mehta, Allyson E. Sgro
The paper normalizes five signal relay network models of Dictyostelium discoideum to assess their ability to reproduce observed population and single-cell dynamics, finding that single-cell excitable dynamics and fold-change detection are essential for robust coordination.
bioRxiv · Sep 2, 2021 · PreprintSystems Biology