fuNTRp: Identifying protein positions for variation driven functional tuning
Maximilian Miller, Dan Vitale, Peter C. Kahn, Burkhard Rost, Yana Bromberg
The paper introduces funtrp, a method to classify protein positions as neutral, rheostat, or toggle based on mutational impact, showing these types correlate with functional effects and improve variant effect prediction.
Nucleic Acids Research · Sep 12, 2019Peer-reviewedBioinformatics