A Linear Mixed Effects Model for Evaluating Synthetic Gene Circuits
Gina Partipilo, Sarah M. Coleman, Alexis J. Holwerda, Yang Gao, Ismar E. Miniel Mahfoud, Claus O. Wilke, Hal S. Alper, Benjamin K. Keitz
The paper introduces a linear mixed effects model to statistically evaluate synthetic gene circuits, finding that the fixed effect β describes gate behavior and can be used to assess performance.
ACS Synthetic Biology · May 11, 2026Peer-reviewedSynthetic Biology