Hal S. Alper

The paper introduces a linear mixed effects model to statistically evaluate synthetic gene circuits, finding that the fixed effect β describes gate behavior and can be used to assess performance.

This paper develops an in situ spectroscopy system for real-time measurement of microbial growth and metabolic activity in simulated microgravity.

This study uses MALDI-TOF mass fingerprints to predict gene ontology annotations in yeast knockouts, identifying new metabolic gene functions.

The paper develops a microdroplet emulsion system to enrich electroactive bacteria and identifies new electrogenic species from environmental samples.

The paper develops a biosensor-AI system to engineer E. coli for efficient production of amaryllidaceae alkaloids, achieving improved titer and reduced byproducts.

This paper evolves highly specific and sensitive biosensors for alkaloids using a combined screening and selection approach, enabling improved microbial production of therapeutic plant metabolites.

This paper evolves a generalist biosensor for bicyclic monoterpenes using directed evolution and a novel screening method.

The paper develops a dynamic regulation network in E. coli to balance malonyl-CoA for enhanced (2S)-naringenin synthesis, achieving an 8.4-fold production improvement with balanced growth.

The paper validates genome-wide CRISPR-Cas9 function in Yarrowia lipolytica by quantifying sgRNA efficiency and identifying high-efficiency guides for 94% of genes.