This study performs a GWAS on asthma exacerbations in the UK Biobank, identifying two novel genetic loci associated with exacerbation risk in individuals with asthma.

ERJ Open Research · Dec 15, 2023Peer-reviewedGenetic & Genomic Medicine

A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables

Julian Hecker, Dmitry Prokopenko, Matthew R. Moll, Sanghun Lee, Wonji Kim, Dandi Qiao, Kirsten R. Voorhies, Woori Kim, Stijn Vansteelandt, Brian D. Hobbs, Michael H. Cho, Edwin K. Silverman, Sharon Marie Lutz, Dawn Lisa DeMeo, Scott T. Weiss, Christoph Lange

RITSS identifies gene-environment interactions in quantitative traits using sample splitting and robust statistics, finding significant interactions in lung function and height data.

PLoS Genetics · Nov 16, 2022Peer-reviewedBioinformatics

The influence of unmeasured confounding on the MR Steiger approach

Sharon Marie Lutz, Kirsten R. Voorhies, Ann Chen Wu, John E. Hokanson, Stijn Vansteelandt, Christoph Lange

This paper examines how unmeasured confounding affects the MR Steiger method's ability to determine causal direction between phenotypes.

Genetic Epidemiology · Feb 16, 2022Peer-reviewedGenetics