Dandi Qiao

The paper develops PACER to infer clonal expansion rates from single timepoint data and identifies TCL1A activation as a mediator of clonal hematopoiesis fitness.

RITSS identifies gene-environment interactions in quantitative traits using sample splitting and robust statistics, finding significant interactions in lung function and height data.

This paper introduces a statistical physics approach using the random-field Ising model to detect disease modules, showing improved efficiency and robustness compared to existing methods.

The paper uses bidirectional Mendelian randomization to show LTL lengthening increases CHIP risk, while CHIP accelerates LTL shortening, with modest mediation between CHIP and CAD via LTL.

This study investigates whether smoking modifies the effect of a polygenic risk score on reduced lung function, finding significant gene-by-smoking interactions in FEV1/FVC.

This paper introduces RUTH, a new HWE test that accounts for population structure and genotype uncertainty, showing it reduces false positives compared to traditional methods.

The paper identifies two SARS-CoV-2 genome loci associated with increased COVID-19 mortality risk using logistic regression on whole-genome sequencing data.

This study expands the genetic landscape of COPD by identifying 82 risk loci, revealing associations with lung function, cell types, and comorbidities.

The paper identifies 279 new genetic signals for lung function across multiple ancestries, showing associations with COPD and pleiotropic effects.