Improved anti-tumor vaccination activity of necroptotic cells lacking ATG16L1-dependent unconventional autophagy
Julia Bandera-Linero, Daniel Oña-Sánchez, Kostantinos Stamatakis, Felipe X. Pimentel‐Muiños
This study shows that blocking ATG16L1-mediated unconventional autophagy in necroptotic tumor cells enhances their ability to induce anti-tumor immunity by increasing ATP secretion and T cell infiltration.
bioRxiv · Oct 19, 2026 · PreprintCancer Biology