Author

Massimo G. Totaro

Graz University of TechnologyORCID 0000-0002-0277-1410Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:diffusion model· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Adrian TrippiD· 1 shared Aleksandar BijeliciD· 1 shared C. FischeriD· 1 shared David B. StolliD· 1 shared Federico RossiiD· 1 shared Gustav OberdorferiD· 1 shared Horst LechneriD· 1 shared Markus Braun· 1 shared

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2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Adrian TrippORCID

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1 paper

Recent·Most cited

BiochemistryNaturePeer-reviewedDec 3, 2025

Computational enzyme design by catalytic motif scaffolding

Markus Braun, Adrian Tripp, Morakot Chakatok…·Gustav Oberdorfer

This paper introduces Riff-Diff, a machine learning and atomistic modeling method for designing enzymes with high catalytic activity and stereoselectivity, demonstrating its effectiveness for two chemical reactions.

80 citationstop 1%

protein structuredeep learning

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