Author

Aleksandar Bijelic

Graz University of TechnologyORCID 0000-0002-8781-153XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Approach:diffusion model· 1 Organism:E. coli· 1

Frequent Co-Authors

David B. StolliD· 2 shared Gustav OberdorferiD· 2 shared Matteo AleottiiD· 2 shared Mélanie HalliD· 2 shared Morakot ChakatokiD· 2 shared Wael ElailyiD· 2 shared Adrian TrippiD· 1 shared Birgit GrilliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersBiochemistry

David B. StollORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 29, 2026

Probing the sequence variability tolerance in a de novo α-helical barrel biocatalyst

Wael Elaily, M. J. BRAUN, David B. Stoll…·Gustav Oberdorfer

This study modifies de novo α-helical barrel biocatalysts using deep learning and computational methods to improve solubility and catalytic performance while maintaining structural stability.

DOI 10.64898/2026.09.28.754888

E. coliprotein structure

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BiochemistryNaturePeer-reviewedDec 3, 2025

Computational enzyme design by catalytic motif scaffolding

Markus Braun, Adrian Tripp, Morakot Chakatok…·Gustav Oberdorfer

This paper introduces Riff-Diff, a machine learning and atomistic modeling method for designing enzymes with high catalytic activity and stereoselectivity, demonstrating its effectiveness for two chemical reactions.

80 citationstop 1%

protein structuredeep learning

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