Xin Wang

Rare genetic variation in VE-PTP is associated with central serous chorioretinopathy, venous dysfunction and glaucoma

The paper identifies a rare variant in VE-PTP associated with CSC, varicose veins, and glaucoma using genome-wide data from multiple cohorts.

Common and Rare Variants Associated with Cardiometabolic Traits across 98,622 Whole-Genome Sequences in the All of Us Research Program

The paper analyzes whole-genome sequences from 98,622 participants to identify common and rare variants associated with cardiometabolic traits, replicating known associations and finding new loci.

Clinical and Therapeutic Applications of Individual-level Tissue-Specific Imputed Transcriptomes

The paper imputes tissue-specific gene expression for 486,452 UK Biobank participants and demonstrates its use in prioritizing therapeutic targets and predicting phenotypic risk.