Author

Michele Maio

University of SienaORCID 0000-0002-0323-6321Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Alessia CovreiD· 4 shared Michele CeccarelliiD· 4 shared Andrea AnichiniiD· 3 shared Anna Maria Di GiacomoiD· 3 shared Francesca Pia CarusoiD· 3 shared Maria Fortunata LofiegoiD· 3 shared Roberta MortariniiD· 3 shared Rossella TufanoiD· 3 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Alessia CovreORCID

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4 papers

Recent·Most cited

GenomicsScience AdvancesPeer-reviewedAug 7, 2026

Transposable Elements and Homotypic Niches Drive Immune Dynamics and Resistance in Melanoma Epigenetic-based immunotherapy

Erika Ciervo, Francesco Ceccarelli, Anna Maria Di Giacomo…·Michele Ceccarelli

This study identifies how epigenetic changes and spatial clustering influence immune dynamics and therapy resistance in melanoma through single-cell and spatial transcriptomics analyses.

DOI 10.1126/sciadv.aed1318

humanscRNA-seq

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Cancer BiologybioRxivPreprintOct 20, 2025

Knowledge-informed multimodal cfDNA analysis improves sensitivity and generalization in cancer detection

Antonio De Falco, Piera Grisolia, Raffaella Giuffrida…·Michele Ceccarelli

Fate-AI improves cancer detection sensitivity and generalization by integrating fragmentomic and methylation features from cfDNA sequencing.

3 citations

humanwhole-genome sequencing

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Cancer BiologyJournal of Experimental & Clinical Cancer ResearchPeer-reviewedJul 18, 2025

Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma

Andrea Anichini, Francesca Pia Caruso, Vincenzo Lagano…·Roberta Mortarini

The paper identifies DNA methylation subtypes in metastatic melanoma and links them to clinical outcomes and immune response, suggesting methylome targeting for precision immunotherapy.

6 citations

humanDNA methylation

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Cancer BiologyJournal of Experimental & Clinical Cancer ResearchPeer-reviewedFeb 18, 2025

DNA methylation status classifies pleural mesothelioma cells according to their immune profile: implication for precision epigenetic therapy

Maria Fortunata Lofiego, Rossella Tufano, Emma Bello…·Alessia Covre

This study shows DNA methylation patterns classify pleural mesothelioma cells into immune profiles, and DHA treatment alters these profiles to improve immune response.

7 citations

humanDNA methylation

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