Andrew E. Lamb

The paper evaluates deconvolution methods for inferring immune infiltration from bulk gene expression using a DREAM Challenge, finding that some community-contributed methods, especially deep learning-based ones, perform well.

The paper identifies FBXO38 as a novel COPD susceptibility gene by analyzing genetically driven alternative splicing and finding a protective exon associated with COPD risk.

The paper identifies ACVR1B as a candidate causal gene for emphysema distribution by integrating GWAS, eQTL, and epigenomic data.