Unlocking substrate specificities of human solute carrier proteins using untargeted metabolomics
Yuesheng Zhang, Lyubomir Dimitrov Stanchev, Felicia Cara Schulz, Daniela Rago, Carlos G. Acevedo‐Rocha, Alberto Santos, Douglas Bruce Kell, Irina Borodina
The paper presents a Xenopus oocyte-based platform to discover transporter substrates using untargeted metabolomics, identifying known and novel substrates for five human SLC transporters.
bioRxiv · Jul 28, 2026 · PreprintSystems Biology