Multiple Functional Neurosteroid Binding Sites on GABAA Receptors
Zi-Wei Chen, John R. Bracamontes, Melissa M. Budelier, Allison L. Germann, Daniel J. Shin, Kathiresan Krishnan, Mingxing Qian, Brad D. Manion, Wayland W.L. Cheng, David E. C. Reichert, Gustav Akk, Douglas F. Covey, Alex S. Evers
The paper identifies three distinct neurosteroid binding sites on the human 1β3 GABAA receptor using photolabeling and computational methods, showing their functional importance in neurosteroid action.
PLoS Biology · Mar 7, 2019Peer-reviewedNeuroscience