RNase 2/EDN cleaves tRNA anticodon loops to generate immunoactive RNAs
Megumi Shigematsu, Atsushi Minami, Takuya Kawamura, Sushrut D. Shah, Tetsuhiro Ogawa, Deepak A. Deshpande, Yohei Kirino
This study identifies EDN/RNase 2 as an endoribonuclease that cleaves tRNA anticodon loops to generate immunostimulatory RNA halves in asthma.
bioRxiv · Sep 10, 2025 · PreprintMolecular Biology