Systematic histone mutagenesis reveals nucleosome-dependent maintenance of three-dimensional chromosome architecture and virulence in Cryptococcus neoformans
Sunhak Kwon, Tu Minh Khuong, Yu-Byeong Jang, Seong-Ryong Yu, Eui-Seong Kim, Sangyong Lim, Jong‐Hyun Jung, Kyung-Tae Lee, Yong‐Sun Bahn, Kwang‐Woo Jung
This study systematically mutagenizes histones in Cryptococcus neoformans to show their role in maintaining 3D chromosome architecture and virulence.
bioRxiv · May 20, 2026 · PreprintMicrobiology