Wolfgang Quapp

Mechanochemical Energy Landscapes Under Force: Catch-Slip Bonds in T-Cell Activation

This paper develops a minimal energy-landscape model to explain how mechanical force affects T-cell activation by reshaping activation barriers and bond lifetimes through catch-slip dynamics.

Comment to: "Topology of molecular deformations induces triphasic catch bonding in selectin-ligand bonds"

The paper challenges mathematical claims about the physical mechanisms of selectin-ligand catch bonding in protein interactions.