Predictive Dynamic Control Accurately Maps the Design Space for 2,3-Butanediol Production
Mathias Gotsmy, Anna Maria Erian, Hans Marx, Stefan Pflügl, Jürgen Zanghellini
This paper uses dynamic control flux-balance analysis to optimize 2,3-butanediol production in E. coli, achieving high titer and productivity through simulation and experimental validation.
Computational and Structural Biotechnology Journal · Oct 28, 2024Peer-reviewedBioengineering