Cristina Parigini

Universal principles of lineage architecture and stem cell identity in renewing tissues

This paper develops a framework to understand lineage architecture and stem cell identity using network science, showing that lineage structures arise from homeostasis and that stemness is context-dependent.

Universality of clonal dynamics poses fundamental limits to identify stem cell self-renewal strategies

The paper shows that stem cell self-renewal models fall into two universality classes with identical clonal statistics under asymptotic conditions, making it difficult to distinguish between models within the same class using clonal data alone.