Author

Clive J. Hoggart

Icahn School of Medicine at Mount SinaiORCID 0000-0002-0482-0052Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 1 Research Focus:polygenic risk· 1 Approach:simulation· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Adam Gordon· 1 shared Amit V. KheraiD· 1 shared Anil P. S. OriiD· 1 shared Atlas KhaniD· 1 shared Bahram NamjouiD· 1 shared C. KachulisiD· 1 shared Candace Guiducci· 1 shared Carla Giner-DelgadoiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Adam Gordon

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2 papers

Recent·Most cited

Stabilising selection enriches the tails of complex traits with rare alleles of large effect

Anil P. S. Ori, Carla Giner-Delgado, Clive J. Hoggart, Paul F. O’Reilly

This study shows that stabilising selection enriches the tails of complex traits with rare alleles of large effect, which may have significant clinical implications.

bioRxiv · Sep 12, 2024 · PreprintGenetics

Selection, optimization, and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse populations

Niall J. Lennon, Leah Claire Kottyan, C. Kachulis, Noura S. Abul‐Husn, Josh Arias, Gillian M. Belbin, Jennifer Elizabeth Below, Sonja I. Berndt, Wendy K. Chung, James J. Cimino, Ellen Wright Clayton, John J. Connolly, David R. Crosslin, Ozan Dikilitas, Digna R. Velez Edwards, , Eimear E. Kenny

The paper selects and validates ten polygenic risk scores for clinical use in diverse populations, focusing on chronic diseases and addressing disparities in predictive performance.

medRxiv · May 25, 2023 · PreprintGenetic & Genomic Medicine