Anil P. S. Ori

The paper identifies departures from polygenic architecture in the tails of complex traits, showing rare alleles are more prevalent and impactful in extreme trait values.

This study shows that stabilising selection enriches the tails of complex traits with rare alleles of large effect, which may have significant clinical implications.

The paper investigates epigenetic age acceleration in schizophrenia, finding age- and sex-specific effects and associations with polygenic risk scores.

The paper evaluates 41 DNA methylation predictors across 101 data preprocessing strategies, finding significant variation in performance and highlighting the importance of appropriate normalization for reliable results.

The paper uses symptom-based case predictions to conduct a GWAS on COVID-19, finding new genetic susceptibility insights and suggesting different genetic architectures for severity and susceptibility.

The paper investigates genetic risk for psychosis spectrum symptoms in youth, finding a significant link with ADHD polygenic scores and age-specific effects.

The paper investigates clozapine's molecular effects using lymphoblastoid cell lines, identifying transcriptomic and epigenomic changes linked to cholesterol and metabolic pathways.

This study examines genetic risk for bipolar disorder in extended families, finding that both common and rare variants contribute to susceptibility, with no significant segregation of large-effect variants.

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.

The paper analyzes whole blood transcriptomes in bipolar disorder patients and finds that lithium treatment, not the disorder itself, drives most gene expression changes.

This study integrates GWAS risk data with longitudinal in vitro gene expression during neuronal differentiation to identify schizophrenia-related gene clusters.

This study identifies 114 genome-wide significant loci for schizophrenia and bipolar disorder, with specific subphenotype associations and four genes distinguishing the disorders.