Comparison of AAV9-driven motor neuron transduction following different CNS-directed delivery methods in mice
Alannah J. Mole, Chiara F Sander, Amisha Parmar, Ailsa J Williams, Mimoun Azzouz, Guillaume M. Hautbergue, Pamela J. Shaw, Laura Ferraiuolo, Richard J. Mead
This study compares AAV9-driven motor neuron transduction efficiency using different CNS delivery methods in mice, finding that unilateral ICV delivery provides the highest and most consistent transduction with minimal peripheral viral copies.
bioRxiv · Jul 1, 2025 · PreprintNeuroscience