Author

Sarah A. Perkins

Broad InstituteORCID 0000-0002-0557-3102Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:DNA methylation· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Angela M. EarlyiD· 3 shared Daniel E. NeafseyiD· 3 shared Ailsa R. CraveniD· 1 shared Ana PinharandaiD· 1 shared Diégo AyalaiD· 1 shared Katrina Kelley· 1 shared Ousman Akone‐Ella· 1 shared Sandrine E. NsangoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 30 mutual co-author links

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3 shared papersEvolutionary Biology

Angela M. EarlyORCID

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3 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintOct 23, 2026

Genotypic evidence of vector-mediated selection on Plasmodium falciparum in infected field-collected Anopheles mosquitoes

Ailsa R. Craven, Ousman Akone‐Ella, Katrina Kelley…·Daniel E. Neafsey

The paper analyzes parasite genotypes in sympatric mosquito species to show divergent selection on Plasmodium falciparum mediated by different vectors.

DOI 10.64898/2026.10.23.759723

DNA methylationstatistical model

Evolutionary BiologybioRxivPreprintOct 20, 2026

Lowly polymorphic pathogen proteins may not be under evolutionary constraint

Ana Pinharanda, Sarah A. Perkins, Angela M. Early, Daniel E. Neafsey

The paper argues that low diversity in pathogen proteins does not necessarily indicate evolutionary constraint and introduces a tool to explore diversity and divergence in Plasmodium falciparum proteins.

DOI 10.64898/2026.10.14.759147

humanmouse

Evolutionary BiologyProceedings of the Royal Society B Biological SciencesPeer-reviewedNov 1, 2025

Heterogeneous constraint and adaptation across the malaria parasite life cycle

Sarah A. Perkins, Daniel E. Neafsey, Angela M. Early

The paper examines how evolutionary forces differ across life stages of Plasmodium falciparum, finding reduced selection efficacy in genes expressed in sporozoites.

2 citations

humanwhole-genome sequencing