Engineering the mechanosensitivity of single DNA molecules via high-throughput microfluidic force spectroscopy
Matthew DeJong, Yujia Bian, Jennifer E. Ortiz-Cárdenas, Bianca Figueroa, Ananya Pant, Eduardo Posadas-Barrera, Lillian Brixi, Magnus S. Bauer, Alexander R. Dunn, Polly Morrell Fordyce
This study introduces SM3FS, a high-throughput microfluidic force spectroscopy method to analyze DNA mechanosensitivity, identifying structures that are kinetically stable but mechanically fragile.
bioRxiv · Feb 25, 2026 · PreprintBiophysics