Improving polygenic prediction from summary data by learning patterns of effect sharing across multiple phenotypes.
Deborah Kunkel, Peter Sørensen, Vijay Shankar, Fabio Morgante
This paper introduces mr.mash-rss, a method for polygenic prediction using GWAS summary statistics, showing improved accuracy over existing methods in various scenarios.
PLoS Genetics · Jan 7, 2025Peer-reviewedGenetics