Vijay Shankar

The paper identifies genetic factors that allow Cryptococcus neoformans to grow without the core septin Cdc12, revealing compensatory mechanisms for septin-independent cell integrity.

The paper introduces DGRP3, an expanded Drosophila genetic reference panel with 1,233 inbred lines, identifying genetic variants and performing GWAS for traits like inbreeding depression and sensory bristles.

This study examines arsenic toxicity in Drosophila brains using single-nuclei RNA sequencing, revealing sex-specific transcriptional responses and linking findings to human neurogenetic networks.

The paper shows that IL-6 induces altered polyadenylation in SERPINA1, increasing long 3UTR isoforms that repress A1AT protein expression during inflammation.

This paper introduces mr.mash-rss, a method for polygenic prediction using GWAS summary statistics, showing improved accuracy over existing methods in various scenarios.

The paper develops a Drosophila model for Fetal Alcohol Spectrum Disorder and finds that developmental alcohol exposure modulates gene and non-coding RNA networks related to nervous system development and ethanol metabolism.

This study examines the physiological and metabolomic effects of reduced brummer lipase expression in Drosophila, revealing sexual dimorphism and metabolic changes relevant to human disorders.

This study examines the effects of developmental alcohol exposure on adult Drosophila phenotypes and brain gene expression, revealing sexual dimorphism and similarities to cocaine-induced gene expression changes.

The paper investigates how single nucleotide polymorphisms in the Drosophila Obp56h gene affect quantitative traits and molecular phenotypes, finding that allelic effects are context-dependent and not captured by traditional additive models.

The paper identifies 59 compounds that inhibit Balamuthia mandrillaris growth and reconstructs its transcriptome to determine potential molecular targets for drug development.

The paper identifies a post-transcriptional regulatory element in the 3UTR of a lifecycle stage-regulated gene in Trypanosoma brucei that mediates glucose-responsive translational control.