BiochemistrybioRxivPreprint
G-quadruplex folding uncouples cis-activation from collateral trans-cleavage by Cas12a
Irina V. Safenkova, Maria V. Kamionskaya, Alexey V. Samokhvalov…·Boris Borisovich Dzantiev
This study shows that G-quadruplex structures can separate Cas12a cis-activation from trans-cleavage, enabling controlled diagnostic signals.
DOI 10.64898/2026.07.23.740342