Endogenous opioid system modulates proximal and distal threat signals in the human brain
Kerttu Seppälä, Vesa Putkinen, Harri Harju, Eleni Rebelos, Jussi Hirvonen, Semi Helin, Johan Rajander, Henry K. Karlsson, Jani P. Saunavaara, Jukka Hyönä, Lauri Nummenmaa
This study investigates how the endogenous opioid system modulates brain responses to threat and safety signals in humans using fMRI and PET.
Molecular Psychiatry · Dec 24, 2025Peer-reviewedNeuroscience