Linnéa Karlsson

Epigenetic and brain age across development: Performance and associations in the MIND consortium

Across 15 cohorts (birth to 24 years), 20 epigenetic clocks and eight brain age models predicted chronological age modestly, stabilizing by middle childhood; their age residuals were weakly associated.

Early life gut microbial and metabolic shifts reflected in stool consistency- a gut transit time proxy

This study links gut transit time, inferred from stool consistency, to microbial metabolites and microbiota in infants, showing associations with breastfeeding, bile acid metabolism, and short-chain fatty acids.

Effortful control and cortical brain structure in 5-year-old children: findings from the FinnBrain birth cohort study

This study examines the relationship between effortful control and cortical brain structure in 5-year-olds using the FinnBrain cohort, finding specific brain regions associated with EC subscales.

Cortical gray matter density at age five associated with preceding early longitudinal language profiles: A Voxel-based morphometry analysis of the FinnBrain Birth Cohort Study

The paper links early language development trajectories to gray matter density in the right superior frontal gyrus at age five using longitudinal data from the FinnBrain Birth Cohort Study.

Functional connectome harmonics capture early brain organization and maturity in neonates

This study uses functional connectome harmonics to analyze neonatal brain gradients and finds that power and energy metrics differ between term and preterm neonates, predicting postmenstrual age.

Functional connectome harmonics and dynamic connectivity maps of the preadolescent brain

The paper applies Functional Connectome Harmonics and Leading Eigenvector Dynamics Analysis to resting-state fMRI data from children to characterize preadolescent brain network organization.

dGAMLSS: An exact, distributed algorithm to fit Generalized Additive Models for Location, Scale, and Shape for privacy-preserving population reference charts

The paper introduces dGAMLSS, a distributed algorithm for fitting GAMLSS models to construct population reference charts without sharing patient data.

Exposure to Maternal Pre- and Postnatal Psychological Distress: Associations with Brain Structure in 5-year-old Children

This study examines how maternal psychological distress before and after birth relates to brain structure in 5-year-olds, finding both positive and negative associations with gray matter volumes in different brain regions.

Temporal Associations Between Human Milk Metabolites and the Infant Gut Microbiome and metabolome

This study examines how human milk metabolites relate to the infant gut microbiome and metabolome over time, finding time-dependent associations and differential influences based on dietary changes.

skiftiTools: An R package for reading, writing, analysing, and visualising, tract-based spatial statistics (TBSS) derived diffusion MR images

skiftiTools enables statistical analysis and visualization of TBSS-derived diffusion MRI data using R, supporting advanced modeling and data manipulation.

Faecal transplantation from exuberant toddlers increases exploratory behaviour in rats

This study transfers exuberant toddler gut microbiota to rats, increasing their exploratory behavior without affecting locomotion or social behavior.

Structural Brain Correlates of Speech Disfluency in Early Childhood: A Dimensional Analysis in a Non-Clinical Cohort

This study examines the structural brain correlates of speech disfluency in 5-year-olds, finding associations between grey matter volume and disfluency without significant sex differences.

Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

This study identifies two ASD subgroups with distinct brain morphology using cross-cultural datasets, highlighting key brain regions associated with subgroup characteristics and autistic traits.

Neonatal White Matter Microstructure Predicts Infant Attention Disengagement from Fearful Faces

The paper links neonatal white matter microstructure to attention disengagement from fearful faces in infants using diffusion MRI and eye tracking.

Pre- and postnatal maternal depressive symptoms associate with local connectivity of the left amygdala in 5-year-olds

The paper examines the association between maternal depressive symptoms and left amygdala connectivity in 5-year-olds, finding a positive link with local ReHo values.

Association between maternal depressive symptoms and hair cortisol concentration during pregnancy with corpus callosum integrity in newborns

The paper examines how maternal depressive symptoms and hair cortisol concentration during pregnancy predict neonatal corpus callosum integrity using MRI and DTI data.

Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity

This study finds a positive association between maternal pre-pregnancy BMI and infant left caudate nucleus mean diffusivity, suggesting in utero exposure to maternal adiposity may impact brain development.

Neonatal Amygdala Mean Diffusivity: A Potential Predictor of Emotional Face Perception

This study examines the relationship between neonatal amygdala microstructure and attention to emotional faces, finding a negative association between amygdala mean diffusivity and disengagement from fearful faces.

The FinnBrain Multimodal Neonatal Template and Atlas Collection: T1, T2, and DTI brain templates, and accompanying cortical and subcortical atlases

The paper introduces a multi-contrast neonatal brain template and atlases to improve image processing and spatial normalization in neonatal neuroimaging.

Attentional bias toward fearful faces is associated with maternal postnatal distress and alterations in white matter microstructure in 5-year-old females

The paper investigates the link between attentional bias toward fearful faces, maternal postnatal distress, and white matter microstructure in 5-year-old females using DTI and eye-tracking data.

Maternal prenatal distress exposure negatively associates with the stability of neonatal frontoparietal network

This study examines how maternal prenatal distress affects neonatal brain network dynamics, finding reduced stability in the frontoparietal network.

Effect of number of diffusion encoding directions in Neonatal Diffusion Tensor Imaging using Tract-Based Spatial Statistical analysis

The paper evaluates the effect of diffusion encoding directions on DTI scalar estimates in neonates using TBSS analysis and finds negligible differences with 24 or more directions.

Structural brain correlates of non-verbal cognitive ability in 5-year-old children: findings from the FinnBrain Birth Cohort study

Exposure to childhood maltreatment is associated with changes in sperm small non-coding RNA and DNA methylation profiles

The paper examines how childhood maltreatment affects sperm small non-coding RNA and DNA methylation profiles in humans, identifying specific epigenetic changes linked to trauma exposure.

Infant Left Amygdala Volume Is Negatively Associated with Fecal Microbiota Diversity

The paper finds a negative association between infant left amygdala volume and fecal microbiota alpha diversity in early life.

Impact of prenatal synthetic glucocorticoid exposure on the adolescent brain

This study examines the long-term effects of prenatal synthetic glucocorticoid exposure on adolescent brain structure and function using MRI, finding no structural differences but altered functional connectivity.

Sex differences, asymmetry and age-related white matter development in infants and 5-year-olds as assessed with Tract-Based Spatial Statistics

The paper uses tract-based spatial statistics to examine sex differences, lateralization, and age-related white matter development in infants and 5-year-olds using diffusion tensor imaging.

Parental childhood maltreatment associates with offspring left amygdala volume at early infancy

The paper examines the association between parental childhood maltreatment and offspring left amygdala volume in early infancy using a birth cohort study.

Associations of Cumulative Paternal and Maternal Childhood Maltreament Exposure with Neonate Brain Anatomy

This study links paternal childhood maltreatment exposure to increased neonate supratentorial grey matter volume, while maternal exposure and BMI show less significant associations.

Feasibility of FreeSurfer processing for T1-weighted brain images of 5-year-olds: semiautomated protocol of FinnBrain Neuroimaging Lab

This paper evaluates the feasibility of using FreeSurfer for processing T1-weighted brain images of 5-year-olds, showing minor effects of manual edits and recommending quality assessment for reliable segmentation.