Bidirectional crosstalk between epithelial-mesenchymal plasticity and IFNγ-induced PD-L1 expression promotes tumor progression
Gerhard A. Burger, Daphne Nesenberend, Carlijn M. Lems, Sander C. Hille, Joost B. Beltman
The paper develops a mathematical model showing bidirectional crosstalk between EMT and IFNγ-induced PD-L1 expression, revealing how they influence tumor progression and immunotherapy resistance.
Royal Society Open Science · Nov 1, 2022Peer-reviewedSystems Biology