Methadone blockade of IK1 promotes both long QT and Brugada-like arrhythmias: Mechanistic insights from computational modeling
Zhaoyang Zhang, J.T. Green, Mark C. Haigney, Kalyanam Shivkumar, Alan Garfinkel, Zhilin Qu
This study uses computational modeling to show that methadone blocks multiple ionic currents, leading to synergistic arrhythmias including long QT and Brugada-like patterns.
bioRxiv · Mar 1, 2025 · PreprintPharmacology & Toxicology