Kalyanam Shivkumar

This paper develops a wireless battery-free implantable device for selective vagus nerve stimulation, demonstrating reduced off-target effects in pigs and a human trial.

This study investigates how NPY affects L-type Ca2+ channel activity in ventricular myocytes before and after myocardial infarction, finding context-dependent stimulatory and inhibitory effects.

This study shows that loss of plexin-mediated cardiac innervation leads to adrenergic hypersensitivity and ventricular arrhythmias in mice, with human PLXNA4 variants linked to arrhythmias.

This study uses computational modeling to show that methadone blocks multiple ionic currents, leading to synergistic arrhythmias including long QT and Brugada-like patterns.

This study compares intrinsic cardiac neurons across humans, mice, and pigs, revealing species-specific differences in structure, function, and neuropeptide expression.

This paper demonstrates spatially-selective vagus nerve stimulation (sVNS) can target cardiac efferent fibers to decrease heart rate without stimulating afferent-related reflexes, improving precision and efficacy of neuromodulation for cardiac disease.

The paper creates a spatially-tracked single-cell transcriptomics map of the right atrial ganglionic plexus, revealing multipotential neuronal phenotypes and a combinatorial neuromodulatory network.

The paper creates a comprehensive neuroanatomic atlas of the RAGP-SAN complex in porcine and human hearts, showing how intrinsic cardiac neurons control SAN automaticity and cardiac function.

The paper identifies peripheral neural circuits regulating heart rate in mice using optogenetic and viral vector strategies, revealing distinct roles of cholinergic and noradrenergic neurons.

This paper describes a protocol for producing and administering AAV-PHP vectors to label and manipulate cells in the mouse nervous system and organs, with guidelines for experimental design.