Adaptive prediction intervals for polygenic risk scores reveal individual variation in genetic predictability
Chen Wang, Fan Wang, Małgorzata Bogdan, Marco Masala, Edoardo Fiorillo, Marcella Devoto, Francesco Cucca, Daniel W. Belsky, Iuliana Ionita‐Laza
This paper introduces a framework for quantifying uncertainty in polygenic risk scores, showing that prediction intervals vary with genetic and environmental factors.
bioRxiv · Oct 13, 2025 · PreprintBioinformatics