Chen Wang

The paper identifies context-dependent genetic regulation of gene expression in pigs using quantile regression, revealing eQTLs that are conserved with humans and influence disease-relevant genes.

This study identifies 36 genetic loci associated with recurrent UTIs and highlights PSCA as a key gene involved in urinary epithelial defense against bacteria.

This study identifies independent associations between IPF risk and rare variants, the MUC5B SNP, and polygenic scores, showing that telomere-associated common variants improve disease prediction and explain genetic heterogeneity in IPF.

This paper introduces a framework for quantifying uncertainty in polygenic risk scores, showing that prediction intervals vary with genetic and environmental factors.

This study identifies RUNX1 as a key regulator of cardiac recovery by reprogramming macrophages, showing that its inhibition promotes heart function recovery in a chronic heart failure model.

The paper demonstrates how quantile regression can correct for subtle population stratification in genome-wide association studies using human height as an example.

This paper develops a method to improve Mendelian randomization analysis by integrating GWAS results across ancestries, enhancing accuracy and power in discovering causal genes for autoimmune diseases.

The paper shows the APOL1 p.N264K variant reduces the risk of FSGS and kidney disease in individuals with G2 APOL1 risk alleles.

The paper introduces MACIE, a framework for predicting functional variants by integrating diverse annotations, and applies it to fine-mapping using GWAS data.

This paper introduces a gene-based testing framework that improves power and reduces false positives by integrating chromatin interactions and knockoff genotypes, showing better performance in GWAS and whole-genome sequencing data.

The paper investigates the association of rare loss-of-function variants in type I IFN immunity genes with severe COVID-19 and finds no significant association.

This paper introduces a statistical method using knockoff statistics to identify causal loci in whole-genome sequencing data, showing increased discovery potential in Alzheimer's and COPD studies.

The paper evaluates 43 methods for predicting intrinsically disordered regions and binding regions in proteins, finding that deep learning methods outperform older physicochemical approaches but binding prediction remains challenging.

The paper identifies neuroprotective genes in retinal ganglion cells by analyzing their resilience to injury using single-cell RNA-seq and functional assays.

The paper reports the chromosome-level genome of the white-spotted bamboo shark and shows chromosome rearrangements contribute to phenotypic diversity in cartilaginous fishes.