Tuning a light-regulated allosteric switch for enhanced temporal control of protein activity
Jacob Matsche, Jordan Fauser, Trisha Bansal, Nicholas Leschinsky, Courtney Coleman, Andrei V. Karginov
This paper enhances an optogenetic tool called LightR by modifying its VVD domains and linker to create variants with improved dynamic range and faster activation kinetics for better control of protein activity.
bioRxiv · Apr 2, 2026 · PreprintSynthetic Biology