Matthew J. Higgs

Placental defects revealed by modelling PWS in mice

The paper shows reduced PWS gene expression in mouse placenta leads to a 25% loss of fetal endothelial cells critical for nutrient transfer.

Tissue-wide scRNA-seq analysis reveals enrichment of imprinted genes in stem and endocrine cell-types in mice

The paper analyzes scRNA-seq data from multiple mouse tissues to show imprinted genes are enriched in stem and endocrine cell types.

Parenting deficits in Magel2-null mice predicted from systematic investigation of imprinted gene expression in galanin neurons of the hypothalamus

The paper identifies Magel2 as an imprinted gene critical for parenting behavior by linking its expression in galanin neurons to behavioral deficits in null mice.

Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution

The paper systematically investigates imprinted gene expression in the mouse brain at single-cell resolution, finding over-representation in neurons and specific brain regions.