Author

Sheng Lian

Hong Kong University of Science and TechnologyORCID 0000-0002-0773-8329Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Organism:human· 1 Assay:long-read sequencing· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Weichuan YuiD· 2 shared Xiaodan FaniD· 2 shared Chen ZhouiD· 1 shared Depeng WangiD· 1 shared Jiandong ShiiD· 1 shared Jingyu HaoiD· 1 shared Ning LiiD· 1 shared Shu WangiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioinformatics

Weichuan YuORCID

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2 papers

Recent·Most cited

gSV: a general structural variant detector using the third-generation sequencing data

Jingyu Hao, Jiandong Shi, Sheng Lian, Zhen Zhang, Yongyi Luo, Taobo Hu, Toyotaka Ishibashi, Depeng Wang, Shu Wang, Xiaodan Fan, Weichuan Yu

gSV improves structural variant detection in long-read sequencing data by integrating alignment and assembly approaches, showing better sensitivity for complex variants and uncovering new SVs in breast cancer.

Briefings in Bioinformatics · May 1, 2026Peer-reviewedBioinformatics

Exhaustive Cross-linking Search with Protein Feedback

Chen Zhou, Shuaijian Dai, Yuanqiao Lin, Sheng Lian, Xiaodan Fan, Ning Li, Weichuan Yu

This paper introduces ECL-PF, a method for cleavable XL-MS data analysis that improves sensitivity in detecting protein-protein interactions and structures.

Journal of Proteome Research · Dec 8, 2022Peer-reviewedBioinformatics