Toyotaka Ishibashi

gSV improves structural variant detection in long-read sequencing data by integrating alignment and assembly approaches, showing better sensitivity for complex variants and uncovering new SVs in breast cancer.

This study identifies H2B.W2 as a spermatocyte-specific histone variant that destabilizes nucleosomes and reduces chromatin compaction, potentially regulating gene expression during spermatogenesis.

The paper identifies Upd2 as a critical factor promoting tumorous growth by converging oncogenic Ras, Yki, and Notch signals in Drosophila imaginal discs.

This study identifies common metabolic and epigenetic changes in fly and human tumors, showing that metabolite depletion drives tumorigenesis across species.

This study identifies H4G, a novel histone variant overexpressed in breast cancer tissues, which localizes to nucleoli and enhances rDNA transcription by destabilizing nucleosomes.