Exploring the effect of Hydrocarbon Cross-linkers on the Structure and Binding of Stapled p53 Peptides
Asha Rani Choudhury, Vikram Gaikwad, Atanu Maity, Rajarshi Chakrabarti
This study uses simulations to analyze how hydrocarbon cross-linkers affect the structure and binding of stapled p53 peptides to MDM2, showing that longer cross-linkers increase rigidity and improve binding efficiency.
Proteins Structure Function and Bioinformatics · Jan 3, 2025Peer-reviewedBiophysics