Author

Stephan A. Frye

Oslo University HospitalORCID 0000-0002-0786-8481Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:deep learning· 2 Assay:protein structure· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alexander Hesselberg LøvestadiD· 3 shared Kristian AlfsnesiD· 3 shared Ole Herman AmburiD· 3 shared Stian Aleksander HelsemiD· 3 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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3 shared papersMicrobiology

Alexander Hesselberg LøvestadORCID

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3 papers

Recent·Most cited

Type IV minor pilin ComN predicted the USS-receptor in Pasteurellaceae

Stian Aleksander Helsem, Kristian Alfsnes, Stephan A. Frye, Alexander Hesselberg Løvestad, Ole Herman Ambur

The paper identifies PpdA as the USS receptor in Pasteurellaceae using structural modeling and coevolution analysis, proposing ComN as its gene name.

Frontiers in Microbiology · Oct 31, 2025Peer-reviewedMicrobiology

Biased enrichment of DNA uptake enhancing sequences in Pasteurellaceae and Neisseriaceae

Stian Aleksander Helsem, Kristian Alfsnes, Stephan A. Frye, Ole Herman Ambur, Alexander Hesselberg Løvestad

This study analyzes DUES distribution and functional associations in 177 genomes, identifying novel DUS dialects and showing functional divergence between Neisseriaceae and Pasteurellaceae.

bioRxiv · Oct 24, 2025 · PreprintEvolutionary Biology

Two different and robustly modeled DNA binding modes of Competence Protein ComP - systematic modeling with AlphaFold 3, RoseTTAFold2NA, Chai-1 and re-docking in HADDOCK

Stian Aleksander Helsem, Kristian Alfsnes, Stephan A. Frye, Alexander Hesselberg Løvestad, Ole Herman Ambur

This study models DNA binding modes of ComP using multiple tools, identifying two robust binding modes that enhance understanding of ComP-DUS interactions.

PLoS ONE · May 8, 2025Peer-reviewedMicrobiology