Author

Stian Aleksander Helsem

OsloMet – Oslo Metropolitan UniversityORCID 0009-0001-4294-3969Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:deep learning· 2 Assay:protein structure· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alexander Hesselberg LøvestadiD· 3 shared Kristian AlfsnesiD· 3 shared Ole Herman AmburiD· 3 shared Stephan A. FryeiD· 3 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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3 shared papersMicrobiology

Alexander Hesselberg LøvestadORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologyFrontiers in MicrobiologyPeer-reviewedOct 31, 2025

Type IV minor pilin ComN predicted the USS-receptor in Pasteurellaceae

Stian Aleksander Helsem, Kristian Alfsnes, Stephan A. Frye…·Ole Herman Ambur

The paper identifies PpdA as the USS receptor in Pasteurellaceae using structural modeling and coevolution analysis, proposing ComN as its gene name.

1 citation

protein structuredeep learning

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Evolutionary BiologybioRxivPreprintOct 24, 2025

Biased enrichment of DNA uptake enhancing sequences in Pasteurellaceae and Neisseriaceae

Stian Aleksander Helsem, Kristian Alfsnes, Stephan A. Frye…·Alexander Hesselberg Løvestad

This study analyzes DUES distribution and functional associations in 177 genomes, identifying novel DUS dialects and showing functional divergence between Neisseriaceae and Pasteurellaceae.

DOI 10.1101/2025.10.24.684340

bacteria (other)DNA methylation

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MicrobiologyPLoS ONEPeer-reviewedMay 8, 2025

Two different and robustly modeled DNA binding modes of Competence Protein ComP - systematic modeling with AlphaFold 3, RoseTTAFold2NA, Chai-1 and re-docking in HADDOCK

Stian Aleksander Helsem, Kristian Alfsnes, Stephan A. Frye…·Ole Herman Ambur

This study models DNA binding modes of ComP using multiple tools, identifying two robust binding modes that enhance understanding of ComP-DUS interactions.

3 citations

bacteria (other)protein structure

𝕏 PostBluesky