A Novel Chromatin-Opening Element for Stable Long-term Transgene Expression
Shireen S. Rudina, Christina D. Smolke
The paper identifies a novel UCOE, SRF-UCOE, that improves transgene stability in mammalian cells by resisting DNA methylation and histone deacetylation compared to existing UCOEs.
bioRxiv · May 3, 2019 · PreprintSynthetic Biology