MULTISCALE ANALYSIS AND VALIDATION OF EFFECTIVE DRUG COMBINATIONS TARGETING DRIVER KRAS MUTATIONS IN NON-SMALL CELL LUNG CANCER
Liana Bruggemann, Zackary Falls, William Mangione, Stanley A. Schwartz, Sebastiano Battaglia, Ravikumar Aalinkeel, Supriya D. Mahajan, Ram Samudrala
The paper validates that osimertinib synergizes with KRAS inhibitors to reduce NSCLC cell proliferation, with MAPK suppression as a key mechanism.
International Journal of Molecular Sciences · Jan 5, 2023Peer-reviewedBioinformatics