Neurotrophin-3 produced by motor neurons non-cell autonomously regulate the development of pre-motor interneurons in the developing spinal cord
Andrea Angla-Navarro, Ana Dominguez Bajo, Mathilde Toch, Cédric Francius, María Hidalgo‐Figueroa, Jingwen Zhang, Mélina Finet, Olivier Schakman, Manon Martin, Xiuqian Mu, René Rezsöhazy, Françoise Gofflot, Frédéric Clotman
The paper shows that Neurotrophin-3 from motor neurons, controlled by Onecut factors, non-cell autonomously regulate pre-motor interneuron development and positioning.
bioRxiv · Jul 27, 2025 · PreprintNeuroscience