Author

Brandon Coke

University of SouthamptonORCID 0000-0002-0847-6885Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Rob M. EwingiD· 3 shared Ahood A. Al-EidaniD· 1 shared Ben Draper· 1 shared Carolini KaidiD· 1 shared Kevin MaringeriD· 1 shared Mahesan NiranjaniD· 1 shared Matt SherwoodiD· 1 shared Mayana ZatziD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

Rob M. EwingORCID

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3 papers

Recent·Most cited

Multiomics analysis reveals key immunogenic signatures induced by oncolytic Zika virus infection of paediatric brain tumour cells

Matt Sherwood, Thiago Mitsugi, Carolini Kaid, Brandon Coke, Mayana Zatz, Kevin Maringer, Oswaldo Keith Okamoto, Rob M. Ewing

This study investigates the immunogenic response of paediatric brain tumour cells to oncolytic Zika virus infection using multiomics approaches, identifying TNF-alpha as a key mediator of oncolytic efficacy and immune activation.

Scientific Reports · Apr 16, 2025Peer-reviewedCancer Biology

sampleclusteR: A lightweight R package for automated clustering of transcriptomics samples using metadata

Brandon Coke, Mahesan Niranjan, Rob M. Ewing

sampleclusteR automates clustering of transcriptomics samples using metadata from GEO and ArrayExpress, correctly grouping most samples across multiple datasets.

bioRxiv · Apr 10, 2025 · PreprintBioinformatics

Knockdown proteomics reveals USP7 as a regulator of cell-cell adhesion in colorectal cancer via AJUBA

Ahood A. Al-Eidan, Ben Draper, Siyuan Wang, Brandon Coke, Paul J. S. Skipp, Yihua Wang, Rob M. Ewing

This study identifies USP7 as a regulator of cell-cell adhesion in colorectal cancer through its interaction with Ajuba, showing reduced adhesion upon USP7 or Ajuba knockdown.

Molecular & Cellular Proteomics · Nov 9, 2024Peer-reviewedSystems Biology