Genome-wide analysis highlights causal epigenetic link to age at menarche
Zhoufeng Ye, Rongbin Xu, George L. Malone, Pierre‐Antoine Dugué, Tuong L. Nguyen, Graham G. Giles, Melissa C. Southey, Roger Laughlin Milne, Shuai Li
The paper identifies a causal epigenetic link between TRIM61 methylation and age at menarche through genome-wide DNA methylation analysis and Mendelian randomisation.
medRxiv · Aug 10, 2025 · PreprintGenetic & Genomic Medicine